RANJANI PRIYA

I am looking for a position as a Junior Genome Analyst within a biotechnology or pharmaceutical organization that fosters a dynamic and collaborative atmosphere. My goal is to engage in groundbreaking research and contribute to the development of new technologies aimed at enhancing our understanding and treatment of significant medical conditions.

Work Experience:

Silvius Technologies

Bioinformatics Intern (4 Months | Stipend: ₹4,000)

• Data Management and Analysis: Collected and curated biological datasets, ensuring accuracy and readiness for computational analysis.
• Programming and Workflow Automation: Developed Python programs to perform bioinformatics tasks such as GC content calculation, complementing DNA sequences, and identifying isoelectric points.
• Sequence Alignment and Phylogenetics: Conducted multiple sequence alignments using Clustal Omega and Clustal W, constructed phylogenetic trees to infer evolutionary relationships, and analyzed results for biological insights.
• Molecular and Structural Biology Analysis: Utilized tools to predict molecular weight and performed gene prediction using Augustus for annotating genomic sequences.
• Tool Development and Applications: Implemented the Golden Gateway Assembly tool to streamline genetic assembly workflows, showcasing adaptability to specialized bioinformatics tools.
• Research and Publications: Reviewed scientific publications to enhance domain knowledge and supported the team in meeting daily task requirements.
• Collaboration and Communication: Successfully completed daily assigned tasks while maintaining effective communication with the team to align project goals with organizational objectives.

Project:

Title: Identifying Drug Targets in a Disease Using Gene Expression Data

Duration: 1 Month

Details: Led a project utilizing cervical cancer gene expression data to identify potential drug targets, employing bioinformatics tools and data analysis techniques. Developed insights into disease pathways, contributing to the identification of promising therapeutic targets. Demonstrated strong research and analytical skills in the field of biomedical informatics.

SYSTEM SKILLS & TOOLS:

• LINUX: Bioinformatics tools and bash scripting, qiime2, mothur, variant calling.
• R Programming: Gene expression data analysis, dplyr, tidyr, ggplot2, deseq2, Knitr, bioconductor.
• Python & Jupyter Notebook: Pandas, Numpy, Matplotlib, Seaborn, Scipy, tkinter. Data Cleaning and Visualization.
• NGS & OMICS Data Analysis: DNA Seq, RNA Seq, and metagenome analysis. Pipeline development using Snake make.
• NGS Tools & Databases: GATK & variant calling using TCGA, WGCNA, Trimmomatic, trimgalore, Cutadapt, FastQC, BWA, Bowtie2, SAMtools, VCFtools.
• Docking: Pyrx | Biological networking – String, Cytoscape.
• AWS: EC2, AWS batch, S3, RDS, EMR, Glacier.
• SQL: Queries to create, handle databases, and retrieve data from a database. Join and Set Operations.

Laboratory Skills:

• Molecular biology techniques: PCR, RT-PCR, DNA/RNA isolation, recombinant DNA, Central dogma of molecular biology.
• Protein purification: Western blotting, ELISA.
• Chromatography: HPLC, TLC, Tissue culture techniques, Mass spectrometry, Electrophoresis – SDS-PAGE.
• Sample Handling: Collection, centrifugation, separation, storage, and shipment of biological samples.
• Equipment Preparation: Labeling and preparing vacutainers, RIA vials, and sample collection stations.

Workshops & Certificates:

• Ethical Edufabrica Workshop in association with Pravega, IISc Bangalore on the topic of Cancer Biology.
• Decode life’s one-month international workshop on the topic of Cancer genomics, 2023.
• An Exposure Training Program in Sugarcane Breeding Institute, Coimbatore on Cultural and Molecular Techniques in Plant Pathology.

Academic Thesis:

• Isolation, Identification, and Characterization of Actinomycetes.
• Comparative Study of Phytochemical Screening, Anti-Oxidant, Anti-Inflammatory, and Anti-Bacterial Activity of Flower Extracts of Dendranthema Grandiflora.

ACADEMIC CREDENTIALS:

• [hidden] Biochemistry (2023) Avinashi Lingam University, Coimbatore
• [hidden] Biochemistry (2021) Kongu Arts and Science College, Erode
• [hidden] (2018) Bharathi Matriculation Higher Secondary School, Erode
• [hidden] (2016) Sri Sathya Sai Matriculation Higher Secondary School, Erode
• Bioinformatics (2023-2024) Certification program at Bversity

Declaration

I declare that the information presented in this resume is true and accurate to the best of my knowledge. I assure you that my experience, skills, and qualifications meet the requirements of the job and I am committed to making a positive contribution to your organization.

Date:

Place: Signature

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Cover Letter:

**Ranjani Priya**

**Date:** [hidden]

**To,**
The Hiring Team,
MedGenome Labs Ltd.,
Bangalore.

**Subject:** Application for the Position of Junior Genome Analyst

Dear Hiring Team,

I am excited to apply for the Junior Genome Analyst position at MedGenome Labs Ltd. With a strong academic foundation in Biochemistry, hands-on experience in bioinformatics, and a passion for genomics, I am eager to contribute to your mission of advancing clinical genomics and delivering cutting-edge diagnostic solutions.

During my internship as a Bioinformatics Intern at Silvius Technologies, I gained extensive experience in NGS data analysis, sequence alignment, and molecular biology techniques. I led a project analyzing cervical cancer gene expression data to identify potential drug targets, showcasing my ability to derive meaningful insights from complex datasets. My proficiency in Python (Pandas, NumPy, Matplotlib, Seaborn, SciPy) and R programming (dplyr, tidyr, ggplot2, DESeq2, Bioconductor) for data analysis and visualization, along with my expertise in bioinformatics tools like Clustal Omega, GATK, Bowtie2, and Snakemake for pipeline development, equips me to handle the technical demands of this role.

In addition to my computational skills, I bring hands-on laboratory experience in molecular biology techniques such as PCR, RT-PCR, DNA/RNA isolation, and recombinant DNA technology. I am also proficient in protein purification techniques like Western blotting and ELISA, as well as chromatography methods including HPLC and TLC. My experience with mass spectrometry, SDS-PAGE electrophoresis, and sample handling (collection, centrifugation, separation, and storage) further strengthens my ability to contribute to both computational and experimental aspects of genomics research.

My academic thesis on the isolation and characterization of Actinomycetes, along with my certification in Bioinformatics from Bversity, has provided me with a solid foundation in genomics and molecular biology. I am particularly drawn to MedGenome’s pioneering work in the GenomeAsia 100K initiative and its commitment to advancing genomic research in Asia.

I am confident that my skills in NGS data analysis, variant interpretation, and molecular biology, combined with my ability to collaborate effectively across teams, align with the requirements of this role. I am excited about the opportunity to contribute to your innovative projects and support the development of molecular diagnostic assays.

Thank you for considering my application. I would welcome the opportunity to discuss how my skills and experiences align with MedGenome’s goals. I am available at your earliest convenience for an interview.

Looking forward to the possibility of contributing to your esteemed organization.

Warm regards,
**Ranjani Priya**