M.Sc. Biotechnology – Unlocking the Secrets of Computational Biology for Groundbreaking Research

PROFILE SUMMARY

[hidden] Biotechnology graduate with hands-on experience in both computational biology and molecular biology. Proficient in bioinformatics tools for data analysis and visualization. Strong problem-solving and strategic planning skills, seeking a role in computational biology to drive impactful research.

WORK EXPERIENCE

AUG 2024 – FEB 2025 Biocon Limited
Research and Development Intern
Nov 2023 – May 2024 Quantumzyme
Research Intern

• Analysing RNA-seq transcriptomic data to identify and interpret differentially expressed genes, supporting insights into gene regulation and expression patterns.
• Biosynthesis Pathway Analysis: Conducted pathway enrichment and mapping to identify key biosynthetic pathways using NGS data, providing insights into metabolic regulation and gene expression.
• Developing an in-house virtual enzyme database and conducting molecular modelling to predict and validate enzyme structures for research applications.
• Learned and applied computational biology techniques, including Molecular Docking, Molecular Dynamics (MD) Simulation, Molecular Modeling, and Quantum Mechanics (QM) calculations, for enzyme engineering.
• Enhanced basic Python programming skills to automate data analysis and explored AI/ML applications in biological research, focusing on predictive modeling and data interpretation.
• Gained proficiency in diverse bioinformatics tools for sequence analysis, protein-ligand interactions, and structural biology applications.

CERTIFICATIONS

One month virtual workshop on Next-Generation Sequencing (NGS) data analysis

HONORS/AWARDS

• Merit Scholarship for the academic year 2019-20.
• Winner at Cease the Disease event, graVITas 2020, VIT University.

EDUCATION

• VELLORE INSTITUTE OF TECHNOLOGY
  [hidden] Integrated Biotechnology
  CGPA: [hidden]
  2019 – 2024
• KENDRIYA VIDYALAYA, INS RAJALI, ARAKKONAM
  XII – [hidden]
  2007 – 2019

LANGUAGES

English (Full Professional)
Tamil (Native or Bilingual)
Hindi (Professional Working)

SKILLS

Bioinformatics, Sequence Analysis, Protein visualization, Homology Modelling, Molecular Docking, Protein-ligand interaction analysis, Molecular Dynamics (MD) Simulation, Quantum Mechanics (QM) calculation, Python (Basic), NGS Data analysis, Transcriptomic analysis, Pathway analysis, Microbial isolation, Phage Multiplication, Double Agar overlay method, Spot test, Centrifugation, UV-spectrophotometer, Gel Electrophoresis, Protein Purification, Microsoft Office Suite (Word, Excel, PowerPoint)

PROJECTS

1. Determination of Klebsiella Bacteriophage Stability
   Studied the Phage Stability in different Solvents and Detergents at various concentrations
2. Halotolerant Bacterial Isolates as Bio-Inoculants for Enhancing Plant Growth
   Examined the halotolerant bacteria’s ability to promote plant growth in Amaranthus under different salinity concentration conditions. Performed Ragdoll method to study the seed germination and Pot experiments were carried out to study the effects of salinity stress on plant growth
3. Analysis of A Novel Protein Structure, Stability, And Function Using Bioinformatics Tools
   Built a protein model structure for a novel protein sequence and analyzed its stability and function using bioinformatics tools
4. Review projects:
   • A Study on the Cassava Mosaic Diseases and its Control Strategies
   • Epidemiology Study on Ebola Virus: Evolution Of The Virus And Its Effects on Different Age Groups
   • Study on Mycoremediation: Role Of Fungi in Bioremediation
   • A Review on the Role of Lactic Acid bacteria in Traditional Plant-Based Fermented Products And Beverages

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Cover Letter:

Ishwarya Lakshmi R
February 12, 2025

Subject: Application for Genome Analyst

Dear HR,

I am excited to apply for the genome analyst at Medgenome. With a background in computational biology and hands-on experience from my internship at Biocon, I am eager to contribute my skills in bioinformatics, data analysis, and computational tools to your team.

During my internship in the Computational Biology team at Biocon, I worked with NGS and transcriptomic data. This experience allowed me to develop strong analytical and problem-solving skills. I am eager to learn and I’m a quick learner.

I am looking forward to apply my expertise in computational biology to support cutting-edge research and contribute meaningfully to your team’s objectives.

I have attached my resume for your review. I would appreciate the opportunity to discuss how my skills align with your team’s needs. Thank you for your time and consideration. I look forward to your response.

Best regards,
Ishwarya Lakshmi R