Aaliya Taiyab
Centre of Interdisciplinary Research in Basic Sciences
Jamia Millia Islamia, New Delhi 110025, INDIA
Short Biography
Aaliya Taiyab is a PMRF Research Fellow at the Drug Design and Discovery Lab, JMI, New Delhi. Her research focuses on structure-based drug design targeting MTH1 for cancer therapeutics. With expertise in protein expression, docking, and cell-based assays, she is dedicated to advancing therapies for cancer and related diseases.
Academic Qualifications
2019-2024
Ph.D. (Interdisciplinary Research) as a PMRF Fellow, Jamia Millia Islamia, New Delhi.
2017-2019
DBT JRF Fellow at Nematology Department, IARI, Pusa Campus, New Delhi.
2015-2017
M.Sc. in Zoology (First Division, 8.3 CGPA) from Aligarh Muslim University, UP.
2012-2015
B.Sc. Hons in Zoology (First Division, 70%) from Daulat Ram College, Delhi University, New Delhi.
Research Profile
Publications in Peer Reviewed Journals
12
Book Chapters
02
Awards/Fellowships
PMRF awarded in 2021
Awarded JRF in the DBT- CoEIB project (ICAR-IARI) in 2018-19.
Qualified GATE 2018, GATE Score: 416, AIR: 1406
Qualified UGC-CSIR-NET 2017 (AIR: 40)
Experimental Skills
Cloning, expression and purification, and characterization of proteins.
Membrane proteins expression and purification.
FPLC and all other chromatographic techniques.
Spectroscopy techniques (CD, UV-Visible, DLS, and fluorescence).
Isothermal Titration Calorimetry (ITC).
Octet® BLI Label-Free Detection Systems for Biomolecular Interactions Analysis.
Macromolecular X-ray Crystallography.
Cell Tissue Culture.
FPLC and HPLC.
Peptide Synthesis and purification
Enzyme immobilization
Bioinformatics Skills: Molecular docking
Featured Publications
S. No. Publication I.F.
Taiyab A, Ashraf A, Sulaimani MN, Rathi A, Shamsi A, Hassan MI. Role of MTH1 in oxidative stress and therapeutic targeting of cancer. Redox Biology 2024, 77:103394. 10.7
Taiyab A, Choudhury A, Haidar S, Yousuf M, Rathi A, Koul P, Chakrabarty A, Islam A, Shamsi A, Hassan MI. Exploring MTH1 inhibitory potential of Thymoquinone and Baicalin for therapeutic targeting of breast cancer. Biomedicine & Pharmacotherapy 2024, 173:116332. 6.9
Gupta P, Taiyab A, Hussain A, Alajmi MF, Islam A, Hassan MI. Targeting the Sphingosine Kinase/Sphingosine-1-Phosphate Signaling Axis in Drug Discovery for Cancer Therapy. Cancers (Basel). 2021, 13(8):1898. 4.5
Rathi A, Khan A, Haider S, Roy S, Taiyab A, Mahendru S, Hussain A, Chakrabarty A, Islam A, Hassan MI, Haque MM. Exploring the potential of baicalin and resveratrol as PIM-1 kinase inhibitors: Therapeutic targeting of prostate and breast cancers. Journal of Molecular Liquids 2024, 396:124026. 5.3
Book Chapters
Gupta, P., Taiyab, A. and Hassan, M.I., 2021. Emerging role of protein kinases in diabetes mellitus: From mechanism to therapy. Advances in protein chemistry and structural biology, 124, pp.47-85.
Shakeel I., Taiyab A., Rathi A., Mohammad T., Afzal M., Hassan MI. Insights into SARS-CoV-2 structure: Approaches and action of SARS-CoV-2 Main Protease Inhibitors. Understanding the Pandemic: Pathophysiology, Transmission and Treatment of COVID-19. (2023)
Conference Proceedings
S. No. Conferences/Symposium/Workshop Awarded best oral presentation at 1st International Interdisciplinary Science Congress: Young Scholar’s Meet (I-ISC-2024) be held at the Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi, on October 9, 2024.
Awarded best poster presentation at “4th World Congress on Drug Discovery and Development” for my work titled as “Unlocking Natural Therapy: Thymoquinone’s role as an MTH1 inhibitor in anticancer treatment” held on 29th October 2023 at IISc Bangalore, India
Skills
Protein Expression, Cloning, Docking, Protein Purification, Cell-Based Assays, Spectroscopy, ITC, X-ray Crystallography, Cell Tissue Culture, FPLC, HPLC, Peptide Synthesis, Enzyme Immobilization, Bioinformatics
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Cover Letter:
I am writing to express my keen interest in the Research Associate (Bio-Curator) position at E-Merge Tech in Chennai. With a strong academic foundation in life sciences and extensive experience in biomedical literature curation and data interpretation, I am confident in my ability to contribute effectively to your team’s mission of integrating and curating complex biological data. As a PMRF Fellow and PhD researcher at the Drug Design and Discovery Lab, Jamia Millia Islamia, I have developed a rigorous understanding of molecular and cell biology, pharmacology, and disease biology. My research on therapeutic targets such as MTH1 has required deep engagement with primary literature and databases like PubMed, UniProt, and ScienceDirect. This aligns seamlessly with your requirements for conducting literature searches, extracting gene/protein/disease data, and synthesizing scientific insights. My work involves critical analysis of data from clinical studies and biochemical assays, which has honed my attention to detail and strengthened my ability to extract meaningful patterns and conclusions. I am adept at generating structured reports and documentation, and I prioritize clarity and precision skills that are vital for this role. Additionally, I have some exposure to bioinformatics resources and I am eager to deepen this expertise. I am enthusiastic about the opportunity to join a purpose-driven and innovation-focused team like E-Merge Tech. I am confident that my research experience, literature analysis capabilities, and scientific acumen make me a strong fit for this position. Thank you for considering my application. I would welcome the chance to discuss how I can contribute to your team’s goals. Sincerely, **Aaliya Taiyab**