BINCY LUKOSE – Discover the Trailblazing PhD Graduate Revolutionizing Biotechnology at IIT Madras!

EDUCATION

PhD in Biotechnology – IIT Madras – CGPA: 9/10 – Year of Completion: 2024
[hidden] Biotechnology – PSG College of Technology, Coimbatore – CGPA: [hidden] – Year of Completion: 2018
[hidden] Biotechnology – University of Kerala, Trivandrum – CGPA: [hidden] – Year of Completion: 2015

RESEARCH PUBLICATIONS

• Bincy Lukose, Takahiro Maruno, Mohammed A Faidh, Susumu Uchiyama, Athi N Naganathan (2024). Molecular and
  thermodynamic determinants of self-assembly and hetero-oligomerization in the enterobacterial thermo-osmo-regulatory
  protein H-NS. Nucleic Acids Res., gkae090.
• Bincy Lukose, Saloni Goyal & Athi N. Naganathan (2025). Oligomerization-mediated Phase Separation in the Nucleoid-associated
  Sensory Protein H-NS is Controlled by Ambient Cues. Protein Sci., 34, e5250
• Chellappa, [hidden], Lukose, B., & Rani, P. (2021). G82S RAGE polymorphism influences amyloid-RAGE interactions relevant in
  Alzheimer’s disease pathology. PLoS ONE, 16.
• Gopi, S., Lukose, B., & Naganathan, [hidden] (2021). Diverse Native Ensembles Dictate the Differential Functional Responses of Nuclear
  Receptor Ligand-Binding Domains. The journal of physical chemistry. B.
• Narayan, A., Gopi, S., Lukose, B., & Naganathan, [hidden] (2020). Electrostatic Frustration Shapes Folding Mechanistic Differences in
  Paralogous Bacterial Stress Response Proteins. Journal of molecular biology.

PROJECTS

• PhD Project: Molecular determinants of self-assembly and hetero-oligomerization in the sensory protein H-NS.
• [hidden] Project: Structural analysis of human glycosylated rage variants – a molecular dynamics simulation study.
• [hidden] Project: Study on potential prebiotic properties of Flacourtia jangomas, Syzygium jambos, individually and combined and
  its effect on antioxidant activity of probiotic bacteria like lactobacillus.

PROFESSIONAL EXPERIENCE

• Research Associate II at IIT Madras in the DBT-funded project “Designing Macromolecular Assemblies with Ordered and High-Complexity
  Disordered Proteins”.
• Teaching Assistant at IIT Madras for [hidden] students.
• Internship at IIT Gandhinagar in the project “Effect of post-translational modification on protein -protein interaction by
  computational methods”.
• Project Trainee at Pelican Biotech and Chemical Labs Pvt Ltd as part of the Biotech Industrial Training Programme.

TECHNICAL SKILLS

• Molecular dynamics simulation: Gromacs
• Genome annotation and data analysis
• Proficiency in protein structure visualization tools: VMD/Pymol
• Language: Matlab
• Operating System: Linux, Windows, CentOS
• Protein characterization techniques: Circular Dichroism Spectroscopy (CD), Equilibrium fluorescence studies, Stopped-Flow
  kinetics, Differential Scanning Calorimetry (DSC)
• Protein purification techniques: Protein expression, FPLC (Affinity/Ion exchange/SEC chromatography)
• Microscopic imaging: Bright field/DIC/Confocal microscopy
• Animal cell culture: Experience in culturing SH-SY5Y human neuroblastoma cell line
• Molecular Biology techniques: DNA, RNA extraction, PCR-RFLP techniques (RT PCR, Colony PCR), transformation, recombinant
  protein overexpression, Western blotting

CONFERENCES

• Presented a poster titled “Molecular and Thermodynamic Determinants of Self-Assembly and Hetero-Oligomerization in the
  Enterobacterial Thermo-Osmo-Regulatory Protein H-NS” at CompFlu 2023 conference held at IIT Madras from 18-20, December 2023
• Presented a poster titled “Homo-versus Hetero-Oligomerization Drives the Thermo-Osmo Responsive Behavior of the
  Enterobacterial Sensory Protein H-NS” at 14th EBSA congress during July 31 – August 4, 2023, in Stockholm, Sweden at Aula Magna
• Presented a poster titled “Dynamic Homo- versus Hetero-Oligomerization Drives the Thermo-Osmo Responsiveness of
  Enterobacterial Sensory Proteins” at the EMBO lecture course on Structure, dynamics, and interactions in biomolecular systems
  using NMR spectroscopy held at IISER Berhampur during 12-16, December 2022

SCHOLASTIC ACHIEVEMENTS

• Best thesis award (2024), IIT Madras
• Secured AIR 150 in GATE 2018
• Secured second rank in [hidden] Biotechnology and Biochemical Engineering program at the university level
• Secured scholarship from AICTE for [hidden] tuition fee

REFERENCES

Dr. Athi N. Naganathan
Professor and DBT/Wellcome Trust IA Fellow
Department of Biotechnology
Indian Institute of Technology Madras (IITM)
Chennai – 600 036, India
Telephone: +91-44-2257 4140
E-mail: [hidden]

Dr. P Rani
Professor
Department of Biotechnology
PSG College of Technology
Coimbatore-641004, India
Telephone: [hidden]
E-mail: [hidden]

SKILLS

Molecular dynamics simulation, Genome annotation, Protein structure visualization, Matlab, Linux, Protein characterization, Protein purification, Microscopic imaging, Animal cell culture, Molecular Biology techniques

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Cover Letter:

**Bincy Lukose**
PhD graduate (2024)
IIT Madras

**Medgenome**
Bangalore

Dear Sir,
I am writing to express my interest in the Genome Analyst position at Medgenome, as advertised on Biotecnika. Although I am transitioning from a research background in Protein Biophysics, I have been taking several courses in genomics, bioinformatics, and data analysis, which have fueled my passion for this field. I am eager to apply my foundational knowledge and analytical skills to contribute to your team’s efforts in advancing genomic research.
During my academic and research career, I developed a strong foundation in biophysical characterization of proteins (Via Spectroscopic/Calorimetric/Modeling), molecular dynamics simulation, molecular biology techniques, data analysis using MatLab and experimental design. I have done my [hidden] thesis work on molecular dynamic simulation in the Gromacs platform, which equipped me to gain some experience in programming languages like Python. Apart from this, the [hidden] course works on Omics have equipped me with the ability to process and interpret genomic data, identify genetic variants, and understand the biological implications of these findings.
While my direct experience in genome analysis is still growing, I bring a strong analytical mindset, attention to detail, and a proven ability to learn quickly. **I have 5 research publications in good impact journals such as Nucleic Acid Research (Impact Factor of [hidden]), Protein Science (Impact Factor of 4), Journal of Molecular Biology (Impact Factor [hidden]), Journal of Physical Chemistry B (Impact Factor of [hidden]), and Plos One (Impact Factor of [hidden]).**
I am confident that my foundational knowledge, enthusiasm for genomics, and dedication to continuous learning make me a strong candidate for this role. I would welcome the opportunity to discuss how my skills and background align with your needs. Thank you for considering my application, and I look forward to the possibility of contributing to Medgenome’s mission.

Sincerely,
Bincy Lukose