Bindumadhuri Cavuturu – Unraveling Cancer Secrets with Cutting-Edge Biotechnology

Introduction Summary:

Name: Bindumadhuri Cavuturu

Qualification: [hidden] in Biotechnology – Drug discovery

Summary: Enthusiastic, Hardworking, and Sincere individual with an immense interest in establishing a career in Life Science research.

Work Experience:

Research Associate-I – National Institute of Pathology, Delhi

April 2023 – August 2024

Project: Screening of Inhibitory Molecules against KIFC1, KIF4A, KIF15, and KIF20A for Breast Cancer Cells

Activities: In-silico screening, MD simulations, MTT assays

Junior Research Analyst – Excelra Knowledge Private Solutions, Hyderabad

March 2021 – March 2023

Education:

[hidden] in Biotechnology – Drug discovery

Pondicherry University, Pondicherry (2012 – 2021)

[hidden] in Biomedical Genetics

Vellore Institute of Technology, Vellore (2009 – 2011)

Achievements:

Publications:

1. Title: Molecular dynamics of interaction of Sesamin and related compounds with the cancer marker β-catenin – Journal of Biomolecular Structure and Dynamics

2. Title: Stabilizers influence drug-polymer interactions and physicochemical properties of disulfiram-loaded poly-lactide-co-glycolide nanoparticles – Future Science Oa

3. Title: Disulfiram and disulfiram-loaded poly-[lactide-co-glycolic acid] nanoparticles modulate metastatic markers and proteasomal activity in hepatocarcinoma Hep3bcell line – [hidden] Nanomed

Conferences Attended:

1. Oral presentation in 36th Annual conference of Indian Association of Bio-medical Scientists

2. Intensive “In-house Training in Animal Cell Culture Techniques”

Contact Details of Referees:

1. Dr. N. Arumugam

Email: [hidden]

Telephone: [hidden]

2. Dr. R. Amutha

Email: [hidden]

Telephone: [hidden]

3. Prof. N. Sakthivel

Email: [hidden]

Telephone: [hidden]

Skills:

Cell Culture, Western Blot, PCR, Human DNA Isolation, Docking, Molecular Dynamic Simulation Studies, Basic Microbial Technologies, Postgraduate Level Skills in Karyotyping

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Cover Letter:

I earned my [hidden] in Biotechnology in February 2021, focusing on drug discovery. My doctoral research centered on targeting β-catenin, a critical driver in 80% of sporadic colorectal cancers, through sesamin and its analogs. By leveraging rigid docking and molecular dynamics (MD) simulations, I identified potent inhibitors, which were subsequently validated through cell-based assays, flow cytometry, and Western blotting in SW480 and HT29 cell lines. This interdisciplinary approach reinforced my ability to bridge computational predictions with experimental validation.

Building upon this foundation, my postdoctoral research expanded my expertise in virtual screening using Schrödinger software and database mining through DrugBank, NCI natural database, and IBS natural compound database. Additionally, I developed doxorubicin-resistant MDA-MB-231 cell lines and conducted cytotoxicity assays to evaluate novel compounds against both standard and drug-resistant cancer cells.

I am confident that my experience aligns with the mission of your team, and I am enthusiastic about the opportunity to contribute to groundbreaking research in this field.

I welcome the opportunity to discuss how my expertise can complement your ongoing research. Thank you for your time and consideration.