Jacob Thomas Joshy – The AI/ML Innovator Revolutionizing Drug Discovery and Biomedical Research

JACOB THOMAS JOSHY
PROJECT SCIENTIST | AI/ML ENGINEER | LLM DEVELOPER | GATE – QUALIFIED
Bangalore, India

EXPERIENCE

Project Scientist I, 05/2023 – 10/2024
NIMHANS – Bangalore

• Promoted from JRF to Project Scientist I within 6 months for significant research contributions.
• Conducted molecular dynamics simulations on neuro-related proteins using AMBER and GROMACS, optimizing ligand interactions for drug discovery.
• Performed manual and HPLC-based purification of BET proteins and carried out protein-ligand crystallization experiments to support structure-based drug design.
• Utilized X-ray crystallography and spectroscopic techniques to analyze protein-ligand structures and refine purification/crystallization protocols.
• Leveraged advanced bioinformatics tools such as MAESTRO, enhancing accuracy by 20%.
• Collaborated with multidisciplinary teams, improving data interpretation workflows by 30% and contributing to the identification of three novel biomarkers.
• Contributed to scientific writing, including research documentation, presentation reports, and experimental summaries for internal reviews and publication planning.

SKILLS

Core AI/ML Stack: XGBoost, PPO, MLP, ResNet-50, SHAP, LSTM, LoRA Fine-Tuning, Temperature Scaling, Platt Scaling, Feature Engineering, Classification & Regression, Confidence Calibration

Tools & Frameworks: Python (Scikit-learn, PyTorch, Pandas, NumPy), Hugging Face Model Hub, ONNX (basic conversion), R, SQL, MySQL

LLMs + Agentic Frameworks: n8n (orchestration), GPT-4o, Claude 3.5, FLAN-T5, SBERT, LangChain, LangGraph, SHAP-to-GPT, Prompt Engineering, Retrieval-Augmented Generation (RAG), FAISS, ChromaDB

Automation, Orchestration & Queues: n8n (Agent Orchestration), Celery + Redis (Async Task Queues), Webhook Logic, Autonomous Agent Execution Loops, Async FastAPI Workers, Scheduler Pipelines

EDUCATION

• Master of Science: Biotechnology [Christ University – Bengaluru, India]
• Bachelor of Science: Biotechnology [Sree Sankara College – Kalady, India]
• GATE Qualified – [2023] | [Biotechnology], Qualified in India’s national-level engineering exam with a score of 434.

PROJECTS & PUBLICATIONS

• ZyncRuit – AI-Powered Resume Matching Platform
  Founder & ML Engineer | Feb 2025 – Present | zyncruit.com
• TwelveC – AI Carbon Intelligence System
  MVP Development in Progress · May 2025 – Present
• Pneumonia Detection – Deep Learning with ResNet-50
  Medical Imaging, PyTorch, CNN, Production Deployment- GitHub Link
• Library Management System – MySQL
  GitHub
• Screening of MTRR variant rs10380 and its In-silico validation in Intracranial Aneurysm
• Lipase and Lactic Acid Bacteria for Biodegradation and Bioremediation

CERTIFICATIONS

• Data Science and Machine Learning – Entri Elevate Program
  Certified by Illinois Institute of Technology 09/2024 – Present
• Biomedical Nanotechnology –- NPTEL
• Software Testing – Manual and Automation – Entri Elevate Program10/2024 – Present
• Python Programming Certification – Entri Elevate Program09/2024 – Present
• Android Development Using Kotlin – Entri Elevate Program 11/2024 – Present

DATA PROCESSING

Data Visualization & Explainability Power BI · Excel Dashboards · SHAP Plots · KPI Reports · Model Confidence Graphs · Top-K Simulation Charts · Visual Resume Scoring Interfaces

Soft Skills: Analytical and Problem-Solving Skills, Attention to Detail, Collaboration and Teamwork, Communication and Presentation Skills, Time Management, Continuous Learning

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Cover Letter:

Dear Hiring Team at D-NOME Biosciences,

I am writing to express my strong interest in the Molecular Biology Scientist position at your esteemed organization. With over two years of focused experience in molecular biology, recombinant protein purification, and structure-based drug design, I am confident in my ability to contribute effectively to your cutting-edge research initiatives.

At NIMHANS, I led key experimental workflows involving protein-ligand crystallization, HPLC purification, and structural analysis using tools like AMBER, GROMACS, and MAESTRO. My earlier tenure at Anthem Biosciences gave me direct exposure to PCR, electrophoresis, fermentation, and bioprocess monitoring. I also hold a GATE qualification in Biotechnology, further underlining my technical foundation.

What excites me most about D-NOME is your integration of recombinant protein workflows with advanced assay development—a domain where I bring both experience and enthusiasm.

I am available to join immediately and am willing to relocate to Hyderabad. Thank you for considering my application.

Warm regards,
Jacob Thomas Joshy